Rebecca is a vivacious 6-year-old girl whose best friend happens to be a germ named Ernest. He's not only Rebecca's best friend ― he's also her partner in mischief, adventure companion, and confidant. Rebecca is spending time in the country with her father, and Ernest of course, when things begin to change. Rebecca befriends a boy who is her age and sees her sister leave to return to the city on her own. Will Ernest & Rebecca's friendship survive?